Palladium‐Catalyzed C(sp³)H Activation: A Facile Method for the Synthesis of 3,4‐Dihydroquinolinone Derivatives

Abstract

Abstract 3,4‐Dihydroquinolinones were synthesized by the palladium‐catalyzed, oxidative‐addition‐initiated activation and arylation of inert C(sp 3 )H bonds. Pd(OAc) 2 and P( o ‐tol) 3 were used as the catalyst and ligand, respectively, to improve the efficiency of the reaction. A further advantage of this reaction is that it could be performed in air. A relatively rare seven‐membered palladacycle was proposed as a key intermediate of the catalytic cycle.