Quantum Dot/Bioluminescence Resonance Energy Transfer Based Highly Sensitive Detection of Proteases

Abstract

Sensing by BRET: Quantum dot (QD) nanosensors can detect the activity of matrix metalloproteinases by measuring the bioluminescence resonance energy transfer (BRET) efficiency between the QDs and a bioluminescent fusion protein (see scheme; Luc8=Renilla luciferase; His×6=six-histidine tag). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700280_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.