Angewandte Chemie International Edition · 2007 · 274 citations · 30 references
Life SciencesBiotechnologyMolecular BiologyBiophotonicsBiosensorsNanobiotechnologyBioluminescenceNanosensorsOptical BiosensingOptical BiosensorsQuantum DotsQuantum Dots In BiologyBioluminescence Resonance Energy TransferBioluminescent ProbesBiomolecular DetectionFluorescence Resonance Energy TransferMatrix MetalloproteinasesNanoparticle-based ProbesQuantum Dot BiosensorsQuantum Dot Sensors
Sensing by BRET: Quantum dot (QD) nanosensors can detect the activity of matrix metalloproteinases by measuring the bioluminescence resonance energy transfer (BRET) efficiency between the QDs and a bioluminescent fusion protein (see scheme; Luc8=Renilla luciferase; His×6=six-histidine tag).
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