An N<i>‐</i>Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirooxindole Lactones

Abstract

Durch kooperative Katalyse gelingt die enantioselektive formale [3+2]-Addition von α,β-ungesättigten Aldehyden an Isatine. Diese Homoenolatcyclisierungen von β-Arylenalen mit einem N-heterocyclischen Carben (NHC) als Katalysator ergeben erst bei Zusatz von Lithiumchlorid hohe Enantioselektivitäten. Als Anwendungsbeispiel wird die Totalsynthese von Maremycin B vorgestellt. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.