Self‐Assembly of Disorazole C₁ through a One‐Pot Alkyne Metathesis Homodimerization Strategy

Abstract

Abstract Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne‐metathesis‐based homodimerization approach to natural products. In this approach to the cytotoxic C 2 ‐symmetric marine‐derived bis(lactone) disorazole C 1 , a highly convergent, modular strategy is employed featuring cyclization through an ambitious one‐pot alkyne cross‐metathesis/ring‐closing metathesis self‐assembly process.