The Catalytically Active Copper‐Amyloid‐Beta State: Coordination Site Responsible for Reactive Oxygen Species Production

Abstract

Kupferionen (rote Kugel im Bild) akkumulieren in Amyloid-β-Plaques und spielen dort eine Rolle bei der Erzeugung reaktiver Sauerstoffspezies (ROS). Massenspektrometrische Studien zeigen, an welchen Stellen eine oxidative Schädigung auftritt, was neue Einblicke in den Mechanismus der ROS-Produktion bietet und dadurch zum besseren Verständnis der Pathogenität von Amyloid-β-Peptiden beiträgt. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.