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Process Development of Halaven®: Synthesis of the C14-C35 Fragment via Iterative Nozaki-Hiyama-Kishi Reaction-Williamson Ether Cyclization
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2013
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Materials ScienceChemical EngineeringCross-coupling ReactionEngineeringSupramolecular AssemblyC14-c35 FragmentProcess DevelopmentFixed EquipmentOrganic ChemistryCatalysisChemistryHalogenationSynthetic ChemistryMultikilogram Manufacturing ProcessConvergent Assembly
Multikilogram manufacturing process of the Halaven<sup>®</sup> C14–C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment.