Concepedia

Dirhodium Carboxylates Catalyzed Enantioselective Coupling Reactions of α‐Diazophosphonates, Anilines, and Electron‐Deficient Aldehydes

Cong‐Ying Zhou, Jing‐Cui Wang, Jinhu Wei, Zhen‐Jiang Xu, Zhen Guo, Kam‐Hung Low, Chi‐Ming Che

Angewandte Chemie · 2012 · 30 citations · 39 references

DOI

Concepts

Abstract

Chirale Dirhodium-Carboxylat-Komplexe ([Rh2(S-PTAD)4] oder [Rh2(S-PTTL)4], siehe Schema) katalysieren effizient die asymmetrische Dreikomponenten-Kupplungsreaktion von α-Diazophosphonaten, Anilinen und elektronenarmen Aldehyden zu α-Amino-β-Hydroxyphosphonaten. Das hohe Maß an Enantiokontrolle ist ein Hinweis darauf, dass der produktbildende Schritt über ein metallgebundenes Ammonium-Ylid verläuft.

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