Catalytic Enantioselective Synthesis of N,C^α,C^α‐Trisubstituted α‐Amino Acid Derivatives Using 1<i>H</i>‐Imidazol‐4(5<i>H</i>)‐ones as Key Templates

Abstract

Abstract 1 H ‐Imidazol‐4(5 H )‐ones are introduced as novel nucleophilic α‐amino acid equivalents in asymmetric synthesis. These compounds not only allow highly efficient construction of tetrasubstituted stereogenic centers, but unlike hitherto known templates, provide direct access to N‐substituted (alkyl, allyl, aryl) α‐amino acid derivatives.