Pomelo Peel Essential Oil Ameliorates Cerebral Ischemia‐Reperfusion Injury through Regulating Redox Homeostasis in Rats and SH‐SY5Y Cells

Abstract

In vitro and in vivo, we verified and investigated the neuroprotective effects of PPEO on CIRI. The underlying process may be connected to redox homeostasis regulation, which enhances antioxidative capacity through upmodulation of SLC7A11 and GPX4. It implies that PPEO will be considered as a source of potential adjuvant therapeutic agents for improving CIRI outcomes.