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Publication | Open Access

Hepatic SIRT6 Modulates Transcriptional Activities of FXR to Alleviate Acetaminophen-induced Hepatotoxicity

DOIFull Paper Access

23

Citations

51

References

2022

Year

Changhui Liu, Zhisen Pan, Zhou-Li Wu, Kaijia Tang, Yadi Zhong, Yingjian Chen, Xiaoxia Xiao, Jingyi Guo, Siwei Duan, Tianqi Cui,
Cellular and Molecular Gastroenterology and Hepatology

Abstract

Our current study suggests that SIRT6 plays a crucial role in APAP-induced hepatotoxicity, and pharmacological activation of SIRT6 may represent a novel therapeutic strategy for APAP overdose-induced liver injury.

References

YearCitations

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