Insulin reduces pyroptosis-induced inflammation by PDHA1 dephosphorylation-mediated NLRP3 activation during myocardial ischemia-reperfusion injury - Concepedia

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Insulin reduces pyroptosis-induced inflammation by PDHA1 dephosphorylation-mediated NLRP3 activation during myocardial ischemia-reperfusion injury

15

Citations

29

References

2022

Year

Sisi Pan, Feng Wang, Yong-peng Hui, Kaiyuan Chen, Zhou Liu, Weilong Gao, Hongkun Wu, Deng-sheng Zhang, Si-yuang Yang, Xuanyi Hu,

Abstract

Results suggest that insulin protects against MIRI by regulating PDHA1 dephosphorylation, its mechanism is not only to improve myocardial energy metabolism but also to reduce the NLRP3-induced pyroptosis.

References

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