Combination of phage therapy and cefiderocol to successfully treat <i>Pseudomonas aeruginosa</i> cranial osteomyelitis

Abstract

This report adds to the growing literature that phage therapy may be a safe and effective approach to augment antibiotic therapy for patients infected with drug-resistant pathogens. Furthermore, it highlights the importance of the GES β-lactamase family in contributing to inactivation of a broad range of β-lactam antibiotics in <i>P. aeruginosa</i>, including ceftolozane/tazobactam, ceftazidime/avibactam and imipenem/relebactam.