Copper catalyzed dearomatization by Michael-type addition of indolyl ynones: divergent synthesis of functionalized spiroindoles and cyclopenta[<i>c</i>]quinolin-3-ones

Abstract

Described herein is a copper-catalyzed multifunctionalization of indolyl ynones, allowing the synthesis of dihalogen-substituted spiroindoles. This Cu catalysis is also applicable to the synthesis of cyclopenta[ c ]quinolin-3-ones via decarbonylation.