Formulation Development and Evaluation of Microemulsion Based Lornoxicam Gel

Abstract

The objective of the existing research was formulation development and preparation of microemulsion loaded emulgel in augmenting the topical delivery of Lornoxicam. Emulsion and gel combined are recognized as Emulgels. Gelling agents Carbopol 940, 974, 980 were used to formulating Lornoxicam emulgel. The drug release from emulgel was determined depending on the different gelling agents. Clove oil for internal phase and Polyethylene glycol 200 was applied as co-surfactant and Tween 20 as permeation enhancer. Prepared emulgels were evaluated for in-vitro and in- vivo anti-inflammatory activity using Albino mice and stability studies. The optimized batch of emulgel gave better results when compared with the marketed Diclofenac sodium gel. 90.42% drug release was detected in 8 hr. Prepared formulation was free from skin irritation and detected with 62.02% inhibition of edema. Correspondingly, prepared formulations were found to be stable. Developed microemulsion increased solubility of drugs, so that less soluble drugs can be applied in the formulation. Carbopol 980 (1.5 %) gave better results for emulgel. Therefore, microemulsion-loaded Lornoxicam Emulgel detected with better analgesic effect.