Efficacy and safety of pramipexole in Parkinson’s disease with anxiety or depression: a meta-analysis of randomized clinical trials

Abstract

Background: To investigate the efficacy and safety of pramipexole in Parkinson’s disease with anxiety or depression by analyzing the randomized clinical trials (RCTs). Methods: National Library of Medicine (PubMed), Cochrane Library of EMBASE, CNKI, VIP and Wanfang database were retrieved to conduct a meta-analysis. We performed sensitivity analysis to assess the efficacy and safety of pramipexole in Parkinson’s disease with anxiety or depression. Results: In our study, the results showed that the efficiency was significantly improved in patients with Parkinson’s disease of the experimental group (fixed effect model, SMD = 3.45, 95% CI = [2.50, 4.76]). The HAMD score of experimental group was lower than that of control group. Moreover, adverse events of experimental group were lower than that of control group. Conclusions: The research demonstrated that pramipexole may improve the efficacy and HAMD score of Parkinson’s disease with anxiety or depression. Due to the limited number of included studies, more RCTs are needed to investigate the effect of pramipexole in Parkinson’s disease with anxiety or depression.