Tuning the Physicochemical Properties of BODIPY for Bioimaging via <i>meso</i>-Amino Acylation

Abstract

A series of BODIPY probes with a wide emission range were prepared via aminoacylation at the <i>meso</i>-position. Functional moieties were also introduced to induce bathochromic shifts in emission, improve water solubility, increase Stokes shifts, and construct bioorthogonal turn-on probes. The developed analogues were successfully used in live-cell imaging, suggesting that the described strategy can be used to prepare probes with improved bioimaging potential.