Application of deep eutectic solvents in bioanalysis

Abstract

The application of deep eutectic solvents (DESs) is sharply surging as a green alternative to conventional solvents due to their unique properties in terms of simplicity of preparation, designability and low cost. A great deal of attention has been paid to the application of these green solvents in analytical chemistry in recent years, and a lot of interesting work has been reported. This review summarizes the most relevant applications of DESs in bioanalysis related to both sample preparation and analyte quantification. Special attention is devoted to the discussion of practical applications for various types of biological samples (blood, plasma, serum, urine, saliva, hair, tear, sweat), with a focus on the advantages of DES-based methods over traditional ones. We cover the articles that were available online up to the end of January 2022. The applications of the reported techniques are summarized in tables.