The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients

Abstract

HBOT reduces host neutrophil STAT3 and azurophilic granule activity in UC patients and changes in microbial composition and metabolism in ways that improve colitis activity. Intestinal microbiota, especially strain level variations in A muciniphila, may contribute to HBOT non-response.