Association of Long-term Ambient Fine Particulate Matter (PM2.5) and Incident CKD: A Prospective Cohort Study in China

Abstract

Exposure to a form of air pollution known as fine particulate matter (ie, particulate matter ≤2.5 μm [PM_2.5]) has been linked to an increased risk of chronic kidney disease (CKD), but little is known about how PM_2.5 affects CKD in regions with extremely high levels of PM_2.5 pollution. This longitudinal cohort study in China investigates the effect of PM_2.5 on the incidence of CKD and whether temperature or humidity interact with PM_2.5. Our findings suggest that long-term exposure to high levels of ambient PM_2.5 significantly increased the risk of CKD in mainland China, especially in terms of cumulative average PM_2.5. The associations of PM_2.5 and incident CKD were greater in high-humidity environments. These findings support the recommendation that reducing PM_2.5 pollution should be a priority to decrease the burden of associated health risks, including CKD.