Au³⁺‐Functionalized UiO‐67 Metal‐Organic Framework Nanoparticles: O₂^•− and •OH Generating Nanozymes and Their Antibacterial Functions

Abstract

Abstract The synthesis and characterization of Au 3+ ‐modified UiO‐67 metal‐organic framework nanoparticles, Au 3+ ‐NMOFs, are described. The Au 3+ ‐NMOFs reveal dual oxidase‐like and peroxidase‐like activities and act as an active catalyst for the catalyzed generation of O 2 •− under aerobic conditions or •OH in the presence of H 2 O 2 . The two reactive oxygen species (ROS) agents O 2 •− and •OH are cooperatively formed by Au 3+ ‐NMOFs under aerobic conditions, and in the presence of H 2 O 2. The Au 3+ ‐NMOFs are applied as an effective catalyst for the generation ROS agents for antibacterial and wound healing applications. Effective antibacterial cell death and inhibition of cell proliferation of Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E . coli ) bacterial colonies are demonstrated in the presence of the Au 3+ ‐NMOFs. In addition, in vivo experiments demonstrate effective wound healing of mice wounds infected by S. aureus , treated by the Au 3+ ‐NMOFs.