Interleukin‐13 Receptor α1–Mediated Signaling Regulates <scp>Age‐Associated</scp>/Autoimmune B Cell Expansion and Lupus Pathogenesis

Abstract

Our findings indicate a novel role for IL-13Rα1 in controlling ABC generation and differentiation, suggesting that IL-13Rα1 contributes to these effects by regulating a subset of IL-21-mediated signaling events. These results also suggest that X-linked genes besides TLR7 participate in the regulation of ABCs in lupus.