Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance Enhances Macrophage Infiltration in Glioma Cells

Abstract

SDT regulates intracellular Ca²⁺ signals by upregulating Piezo1 leading to the inhibition of the energy supply from lipid and recruitment of macrophages. Therefore, intervening with the function of the Ca²⁺ channel on the glioma cell membrane in advance is likely to be the key factor to obtain a better effect combined with SDT treatment.