Diversity-oriented synthesis of fluoroalkylated amines <i>via</i> the palladium-catalyzed divergent fluoroalkylamination of 1,3-dienes

Abstract

Herein, we reported the first versatile and expeditious protocol for the diversity-oriented synthesis (DOS) of fluoroalkylated amines <i>via</i> the photoinduced palladium-catalyzed cross coupling of 1,3-dienes, amines and fluoroalkyl iodides, which features excellent 3,4- and 1,4-selectivity controlled by fluoroalkyl iodides, a broad substrate scope as well as good function group tolerance, and could be extended to the late-stage modification of bioactive molecules.