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Preclinical Data on the <i>Gardnerella</i> -Specific Endolysin PM-477 Indicate Its Potential to Improve the Treatment of Bacterial Vaginosis through Enhanced Biofilm Removal and Avoidance of Resistance

Christine Landlinger, Vera Oberbauer, Lenka Podpera Tišáková, Timo Schwebs, Rocío Berdaguer, Leen Van Simaey, Mario Vaneechoutte, Lorenzo Corsini

Antimicrobial Agents and Chemotherapy · 2022 · 33 citations · 32 references

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Concepts

Abstract

biofilms, as well as its high resilience to resistance formation, makes PM-477 a promising potential alternative for the treatment of bacterial vaginosis, especially in patients with frequent recurrence.

References

32

High Recurrence Rates of Bacterial Vaginosis over the Course of 12 Months after Oral Metronidazole Therapy and Factors Associated with Recurrence

Catriona S. Bradshaw, Anna N. Morton, Jane S. Hocking et al. · The Journal of Infectious Diseases · 2006 · 771 citations

, , +16

Vancomycin, Metronidazole, or Tolevamer for Clostridium difficile Infection: Results From Two Multinational, Randomized, Controlled Trials

Stuart Johnson, Thomas Louie, Dale N. Gerding et al. · Clinical Infectious Diseases · 2014 · 523 citations · Full text

, , +13

Adherent Biofilms in Bacterial Vaginosis

Alexander Swidsinski, Werner Mendling, Vera Loening‐Baucke et al. · Obstetrics and Gynecology · 2005 · 473 citations

, , +15

An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole

Alexander Swidsinski, Werner Mendling, Vera Loening‐Baucke et al. · American Journal of Obstetrics and Gynecology · 2007 · 326 citations

, , +13

Molecular Aspects and Comparative Genomics of Bacteriophage Endolysins

Hugo Oliveira, Luís D. R. Melo, Sílvio Roberto Branco Santos et al. · Journal of Virology · 2013 · 302 citations · Full text

, , +17