Validation of dermatopathological criteria to diagnose cutaneous lesions of mastocytosis: importance of <scp><i>KIT</i> D816V</scp> mutation analysis

Abstract

MPCM can be predicted by major and minor criteria combined in a scoring model. Presence of D816V mutation in FFPE skin and MC density > 27/HPF are >95%-specific major criteria for MPCM. MC densities 12/HPF, interstitial MC, clusters and basal pigmentation are minor criteria.