Immune cell atlas of cholangiocarcinomas reveals distinct tumor microenvironments and associated prognoses

Abstract

This study suggests that the densities of Granzyme-B⁺CD8⁺ effector T cells and non-exhausted PD-1^-EOMES^-CD8⁺ T cells and the PD-L1 status in the tumor-associated macrophages are prognostic makers in cholangiocarcinomas. The study also supports targeting PD-L1⁺ tumor-associated macrophages as the immunotherapy for cholangiocarcinoma.