STOP Codon Mutations at Sites of Natural Caspase Cleavage Are Implicated in Autism and Alzheimer’s Disease: The Case of ADNP

Abstract

FIGURE 1 | Human ADNP protease cleavage site (CLV). The picture shows protein cleavage sites in ADNP as obtained from the ELM data base. Highlighted in the text are cleavage sites associated with somatic ADNP mutations in postmortem Alzheimer's disease brains. The ELM site shows ordered and disordered structures within protein, with ordered meaning a three dimensional protein structure.