International Journal of Molecular Sciences · 2022 · 50 citations · 30 references
Life SciencesInfectious DiseasesMaterials ScienceNanobiotechnologyNanomaterialsVirologyAntiviral TherapyInorganic NanoparticlesNanomedicineNanoparticle DesignNanoparticle FormulationsViral VaccinesAntimicrobial NanomaterialsAntimicrobial NanomedicineNanoparticle Antimicrobial AgentsNanoparticlesNanostructuresSemiconductor NanostructuresSevere Acute Respiratory SyndromeViral Load Assessment
In 2019, the new coronavirus disease (COVID-19), related to the severe acute respiratory syndrome coronavirus (SARS-CoV-2), started spreading around the word, giving rise to the world pandemic we are still facing. Since then, many strategies for the prevention and control of COVID-19 have been studied and implemented. In addition to pharmacological treatments and vaccines, it is mandatory to ensure the cleaning and disinfection of the skin and inanimate surfaces, especially in those contexts where the contagion could spread quickly, such as hospitals and clinical laboratories, schools, transport, and public places in general. Here, we report the efficacy of ZnO nanoparticles (ZnONPs) against SARS-CoV-2. NPs were produced using an ecofriendly method and fully characterized; their antiviral activity was tested in vitro against SARS-CoV-2, showing a decrease in viral load between 70% and 90%, as a function of the material's composition. Application of these nano-antimicrobials as coatings for commonly touched surfaces is envisaged.
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Biochemical characterization of SARS-CoV-2 nucleocapsid protein
Weihong Zeng, Guangfeng Liu, Huan Ma et al. · Biochemical and Biophysical Research Communications · 2020 · 527 citations · Full text