Extended-Spectrum Beta-Lactamase- and Carbapenemase-Producing Enterobacteriaceae Family of Bacteria from Diarrheal Stool Samples in Northwest Ethiopia

Abstract

A total of 404 Enterobacteriaceae groups of bacteria were isolated from 384 diarrheal stool samples. The overall prevalence of fecal MDR-, ESBL-, and CPM-producing group of Enterobacteriaceae was 196 (48.5%), 66 (16.3%), and 4 (1%), respectively. Of the total ESBL-producing Enterobacteriaceae, <i>E. coli</i> (41/66 (62.1%)) and <i>K. pneumoniae</i> (18/66 (27.3%)) were the most predominant isolates. One half of CPE has been observed in <i>Citrobacter</i> species and the rest in <i>E. coli</i> (25%) and <i>P. vulgaris</i> (25%). <i>Conclusion and Recommendation</i>. Finding the high rate of ESBL-producing Enterobacteriaceae and CPE requires strict infection control measures and careful selection of empirical therapy in the study area. Therefore, active surveillance with large sample size and better infection prevention control is needed.