Phenotypic Spectrum and Prognosis of Epilepsy Patients With GABRG2 Variants

Abstract

The clinical features of <i>GABRG2</i>-related epilepsy included seizure onset, usually in infancy, and seizures were fever-sensitive. More than half of the patients had cluster seizures. Phenotypes of <i>GABRG2</i>-related epilepsy were ranged from mild febrile seizures to severe epileptic encephalopathies. Most patients with <i>GABRG2</i> variants who experienced seizures had a good prognosis. Valproate and levetiracetam were effective treatments for most patients.