Folate Receptor Expression by Human Monocyte–Derived Macrophage Subtypes and Effects of Corticosteroids

Abstract

As corticosteroids skewed monocytes toward an FR-β-expressing, anti-inflammatory phenotype, even in an M1 priming GM-CSF environment, FR-β has potential as a biomarker to monitor success of treatment with corticosteroids. Without corticosteroid treatment, M-CSF alone induces high FR-β expression which remains high under pro-inflammatory conditions. This explains why pro-inflammatory FR-β⁺ macrophages (exposed to M-CSF) are observed in arthritis patients and correlate with disease severity.