The APOEε3/ε4 Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice

Abstract

<i>APOE^ε4</i> allele dosage-specific effects were observed in circulating lipid levels and cortical transcriptional profiles. Future studies are needed to establish how these data may contribute to therapeutic development in <i>APOE^ε3/ε4</i> and <i>APOE^ε4/ε4</i> dementia patients.