Cimifugin Ameliorates Lipotoxicity‐Induced Hepatocyte Damage and Steatosis through TLR4/p38 MAPK‐ and SIRT1‐Involved Pathways

Abstract

In brief, we demonstrate the protective effects of Cim against lipotoxicity-induced cell death and steatosis in hepatocytes. TLR4-regulated p38 MAPK and SIRT1 pathways are involved in Cim-protected hepatic lipotoxicity. Cim is a potential candidate for improving hepatic metabolic disorders mediated by lipotoxicity.