Detection of recurrent colorectal cancer with high specificity using a reporting threshold for circulating tumor DNA methylated in <i>BCAT1</i> and <i>IKZF1</i>

Abstract

Applying a threshold for positivity to the methylated BCAT1/IKZF1 blood assay improved the specificity for CRC recurrence without compromising sensitivity. Both the sensitivity and the specificity were superior to those of CEA.