Regenerative Medicine · 2022 · 15 citations · 27 references
EngineeringCell BiologyDermatologyRegenerative MedicineTissue EngineeringWound HealingImmunomodulation In RegenerationMesenchymal Stem Cell TherapyMesenchymal Stromal Cell TherapySkin RegenerationWound Healing PhysiologyWound Healing ResponseAngiogenesis In Skin RepairCutaneous Wound HealingExosome-mediated Skin RepairExosomesGrowth FactorsImmunomodulatory CytokinesImmunomodulatory EffectsMurine Models
Background: Skin regeneration from an injury without a scar is still a challenge. Methods: A murine model of a skin wound was treated with a combination of extract of astragalus and exosomes of mesenchymal stem cells (MSCs). CD11b+ and CD45 macrophages were detected and levels of cytokines were tested. Results: The expression of growth factors VEGF, FGF2 and EGF was elevated after treatment administered to MSCs. The administration of ethanolic extract of astragalus decreased the expression of TNF-α, IL-1β and IL-6 and simultaneously increased the levels of IL-10. The combination sped up the process of wound healing. A sustained-release gel with both ingredients was developed to enhance restoration from granulation. Conclusion: The extract of astragalus promotes the efficacy of MSC-derived exosomes in skin repair.
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Arnold I. Caplan, Diego Correa · Cell stem cell · 2011 · 1.7K citations · Full text
Luis A. Ortiz, Maria Dutreil, Cheryl L. Fattman et al. · Proceedings of the National Academy of Sciences · 2007 · 1K citations · Full text
HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing
Bin Zhang, Mei Wang, Aihua Gong et al. · Stem Cells · 2014 · 805 citations · Full text