A novel approach for relapsed/refractory FLT3mut+ acute myeloid leukaemia: synergistic effect of the combination of bispecific FLT3scFv/NKG2D-CAR T cells and gilteritinib - Concepedia

Concepedia

Publication | Open Access

A novel approach for relapsed/refractory FLT3mut+ acute myeloid leukaemia: synergistic effect of the combination of bispecific FLT3scFv/NKG2D-CAR T cells and gilteritinib

DOI Full Paper Access

45

Citations

35

References

2022

Year

Kexin Li, Hui-Yang Wu, Wanying Pan, Mengqi Guo, De-zhi Qiu, Yanjie He, Yuhua Li, Dong‐Hua Yang, Yuxian Huang

Molecular Cancer

Abstract

Bispecific FLT3scFv/NKG2D-CAR T cells can effectively eradicate AML cells. The FLT3 inhibitor gilteritinib can synergistically improve this effect by upregulating NF-κB2-dependent NKG2DL expression in AML cells.

References

	Year	Citations

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