mBio · 2022 · 37 citations · 77 references
Life SciencesInfectious DiseasesMolecular BiologyGene ExpressionInflammationMolecular VirologyInflammatory SignalingMicrorna BiologyMicrorna-mediated RegulationPulmonary InflammationViral PathogenesisViral PathologyInflammatory Lung InjuryLung Immune ResponseMicrorna In Immune RegulationMicrorna In InflammationMicrorna InteractionsMicrorna Regulation Of InflammationMicrorna-protein InteractionsViral Rna-protein Interactions
The SARS-CoV-2 pandemic has emphasized the need to understand the mechanisms of severe lung inflammatory pathology caused by human deadly coronaviruses in order to design new antiviral therapies. Here, we identify miRNA-223-3p as a host miRNA involved in the regulation of lung inflammatory response mediated by envelope (E) protein during SARS-CoV infection. miRNAs downregulate the expression of cellular mRNAs and participate in complex networks of mRNA–miRNA interactions that regulate cellular processes.
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The Sequence Alignment/Map format and SAMtools
Heng Li, Alec Wysoker, Tim Fennell et al. · Bioinformatics · 2009 · 67.5K citations · Full text
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PubMed · 1997 · 66.6K citations