New England Journal of Medicine · 2022 · 371 citations · 52 references
Life SciencesEndocrinologyPhysiologyMetabolic PhysiologyMetabolic RegulationPathophysiologyAdipose TissueBody CompositionBody Composition ChangesEndocrine PhysiologyInsulin ResistanceMetabolic EndocrinologyAdipose Tissue BrowningAdipose Tissue ChangesAdipose Tissue EndocrinologyBrown Adipose Tissue ActivationBrown Adipose Tissue BioenergeticsBrown Adipose Tissue MetabolismObesity PhysiologyWhite Adipose Tissue Biology
Adipose tissue can more than double in mass and then return to baseline. This review discusses the functional roles of human white and brown adipose tissue and its excess in obesity, as well as its far-reaching, complementary physiological roles in the endocrine system.
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