Publication | Open Access
Coordination complexes constructed from pyrazole–acetamide and pyrazole–quinoxaline: effect of hydrogen bonding on the self-assembly process and antibacterial activity
20
Citations
48
References
2022
Year
Two mononuclear coordination complexes of <i>N</i>-(2-aminophenyl)-2-(5-methyl-1<i>H</i>-pyrazol-3-yl)acetamide (L<sub>1</sub>), namely [Cd(L<sub>1</sub>)<sub>2</sub>Cl<sub>2</sub>] (C<sub>1</sub>) and [Cu(L<sub>1</sub>)<sub>2</sub>(C<sub>2</sub>H<sub>5</sub>OH)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub> (C<sub>2</sub>) and one mononuclear complex [Fe(L<sub>2</sub>)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](NO<sub>3</sub>)<sub>2</sub>·2H<sub>2</sub>O (C<sub>3</sub>), obtained after <i>in situ</i> oxidation of L<sub>1</sub>, have been synthesized and characterized spectroscopically. As revealed by single-crystal X-ray diffraction, each coordination sphere made of two heterocycles is completed either by two chloride anions (in C<sub>1</sub>), two ethanol molecules (in C<sub>2</sub>) or two water molecules (in C<sub>3</sub>). The crystal packing analysis of C<sub>1</sub>, C<sub>2</sub> and C<sub>3</sub>, revealed 1D and 2D supramolecular architectures, respectively, <i>via</i> various hydrogen bonding interactions, which are discussed in detail. Furthermore, evaluation <i>in vitro</i> of the ligands and their metal complexes for their antibacterial activity against <i>Escherichia coli</i> (ATCC 4157), <i>Pseudomonas aeruginosa</i> (ATCC 27853), <i>Staphylococcus aureus</i> (ATCC 25923) and <i>Streptococcus fasciens</i> (ATCC 29212) strains of bacteria, revealed outstanding results compared to chloramphenicol, a well-known antibiotic, with a normalized minimum inhibitory concentration as low as 5 μg mL<sup>-1</sup>.
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