Overexpression of CD168 is related to poor prognosis in oral squamous cell carcinoma

Abstract

Abstract Objectives Receptor for hyaluronic acid (HA)‐mediated motility (RHAMM) is also known as CD168. This study proposed to elucidate the prognostic and clinicopathological significance of CD168 expression in oral squamous cell carcinoma (OSCC). Materials and methods Immune staining of a human tissue microarray and Western blot were used to reveal the expression level of CD168 in OSCC. Correlations between clinicopathological indexes and CD168 expression in OSCC patients were assessed. Results Increased expression of CD168 was detected in OSCC tissues. High expression of CD168 indicated worse survival of patients ( p < .05). Furthermore, high expression of CD168 was related to pathological grade in OSCC ( p < .05). CD168 expression was positively related to programmed death ligand 1 (PD‐L1), CKLF‐like MARVEL transmembrane domain‐containing protein 6 (CMTM6), B7 homology 4 protein (B7‐H4), CD44, CD133, and Slug expression in OSCC. Conclusion This study revealed the overexpression of CD168 in OSCC and shed light on the prognostic significance of CD168 expression in OSCC patients.