Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205–5p/PTEN/AKT pathway

Materials fabrication from Bombyx mori silk fibroin

Danielle N. Rockwood, Rucsanda C. Preda, Tuna Yücel et al. · Nature Protocols · 2011 · 2.9K citations · Full text

Materials Science, Engineering, Silk Fibroin +2

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

Shipin Zhang, S. Chuah, Ruenn Chai Lai et al. · Biomaterials · 2017 · 918 citations

Regenerative Medicine, Extracellular Vesicles, Cell Therapy +14

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

Shi‐Cong Tao, Ting Yuan, Yue-Lei Zhang et al. · Theranostics · 2016 · 706 citations · Full text

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

Wei Liu, Yuluo Rong, Jiaxing Wang et al. · Journal of Neuroinflammation · 2020 · 589 citations · Full text

Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac repair through miR-125b-mediated prevention of cell death in myocardial infarction

Lingping Zhu, Tian Tian, Junyao Wang et al. · Theranostics · 2018 · 547 citations · Full text