Differential DNA methylation analysis of <i>SUMF2</i>, <i>ADAMTS5</i>, and <i>PXDN</i> provides novel insights into colorectal cancer prognosis prediction in Taiwan

Abstract

Our study found that CpG_3+CpG_7 hypermethylation of <i>SUMF2</i> from tumor tissue was associated with significantly shorter PFS and OS compared with CpG_3+CpG_7 hypomethylation. CpG_2 and CpG_13 hypermethylation of <i>ADAMTS5</i> from normal tissue was associated with a significantly longer RFS compared with CpG_2 and CpG_13 hypomethylation. These methylation-related biomarkers which have implications for CRC prognosis prediction may aid physicians in clinical decision-making.