KIAA1199 drives immune suppression to promote colorectal cancer liver metastasis by modulating neutrophil infiltration

Abstract

These findings indicated that KIAA1199 could facilitate the liver infiltration of immunosuppressive neutrophils via the TGFβ-chemokine (C-X-C motif) ligand (CXCL)3/1-CXCR2 axis, which might be clinically targeted for the treatment of hepatic metastasis.