Co-delivery of Chemotherapeutic Drugs and Immune Adjuvants by Nanoscale DNA Tetrahedrons for Synergistic Cancer Therapy

Abstract

Chemoimmunotherapy represents an attractive approach for cancer treatment, which requires a compatible co-delivery system to achieve the synergetic therapeutic effects. Among various nanocarriers, DNA nanostructures have recently been proposed as promising candidates for drug delivery system due to the excellent biocompatibility. Herein, we employ DNA tetrahedron to create a co-delivery nanoplatform that combines the chemotherapeutic drug doxorubicin and the immunotherapeutic agent CpG oligodeoxynucleotides. The DTN-CpG/DOX nanoparticles show synergistic therapeutic effects in terms of enhanced immunostimulatory activity and pronounced antitumor efficiency. The simultaneous loading drugs with modifiable DNA nanostructures represent an attractive strategy for facile delivery of various therapeutic components.