Cell Metabolism · 2022 · 49 citations · 69 references
Life SciencesImmunologyPathobiologyAutoimmunityImmunopathologyInflammationAutoimmune Disease PathogenesisAutoimmune DiseasesAutoimmune PathogenesisDendritic Cell BiologyDendritic Cell RegulationImmune CheckpointsAntiviral T Cell ResponsesCd8 Positive T Cell ResponsesCd8 Positive T CellsCd8 T Cell ActivationDendritic Cell Antiviral ResponsesDendritic Cell Inflammatory ResponsesDendritic Cell-driven T Cell PrimingT Cell Expansion
-dependent manner by balancing flux through adenine-guanine nucleotide interconversion cycles. FAMIN additionally converts hypoxanthine into inosine, which DCs release to dampen T cell activation. Compromised FAMIN consequently enhances immunosurveillance of syngeneic tumors. FAMIN is a biochemical checkpoint that protects against excessive antiviral T cell responses, autoimmunity, and autoinflammation.
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T cell receptor antagonist peptides induce positive selection
Kristin A. Hogquist, Stephen C. Jameson, William R. Heath et al. · Cell · 1994 · 2.9K citations
Longitudinal analyses reveal immunological misfiring in severe COVID-19
Carolina Lucas, Patrick Wong, Jon Klein et al. · Nature · 2020 · 2.3K citations · Full text