Molecular mechanism of CK19 involved in the regulation of postoperative recurrence of HBV-associated primary hepatocellular carcinoma in Guangxi

Abstract

Among HBV-related recurrent HCC, the positive rate of <i>CK19</i> expression in recurrent HCC tumors was higher, and the tumor-free survival time of HCC patients with positive <i>CK19</i> expression in primary HCC was shorter. After silencing of the <i>CK19</i> gene, the migration and invasion ability of HCC cells were weakened, the content of G2-M cell cycle cells was increased, the invasion and migration of HCC cells were inhibited, and apoptosis was promoted. Changes in the function of the cell cycle regulating genes and the regulation of drug and carcinogenic metabolites-related pathways may be the pathways through which <i>CK19</i> affects the biological behavior of HCC.