Transient increase in recurrent inhibition in amyotrophic lateral sclerosis as a putative protection from neurodegeneration

Abstract

We provide the first evidence for enhanced recurrent inhibition and speculate that Renshaw cells might have transient protective role on motoneuron by counteracting hyperexcitability at early stages. Several mechanisms likely participate including cortical influence on Renshaw cell and reinnervation by slow motoneurons.