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Neonatal Effects of Maternal Clomipramine Treatment
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1982
Year
FertilityPsychotropic MedicationPsychopharmacologyHigh-risk PregnancyUnnoticed ProblemPrenatal CareObstetricsPublic HealthPsychiatryDepressionMaternal HealthTricyclic Antidepressant ClomipramineNeuropharmacologyMaternal-fetal MedicinePediatricsMaternal Clomipramine TreatmentPregnancyPregnant WomenBiological PsychiatryMedicinePsychopathology
This paper calls attention to a relatively unnoticed problem, ie, morbidity in neonates caused by treatment of pregnant women with the tricyclic antidepressant clomipramine (Anafranil). Recently we have seen identical clinical pictures in two neonates born to mothers treated throughout pregnancy with clomipramine because of an endogenous depression (200 mg daily in case 1 and 100 mg daily in case 2). Both babies were delivered without complications at term after otherwise uneventful pregnancies. CASE REPORTS Case 1 Physical examination of the neonate at birth revealed the following: birth weight, 3,550 gm; height, 52 cm; and head circumference, 34.6 cm. Apgar scores were 9 at one minute and 10 at five minutes.