PM2.5 induces inflammatory responses via oxidative stress-mediated mitophagy in human bronchial epithelial cells

Abstract

PM_2.5 induced cellular inflammatory injury by oxidative stress, mitochondrial dysfunction, and mitophagy initiation. Although induction of Bnip3L/NIX-mediated mitophagy in BEAS-2B cells appeared to confer protection in response to PM_2.5, dysfunction of autophagic flux may be a critical contributor to defective mitophagy and cellular inflammatory response.