BDJ · 2021 · 318 citations · 22 references
DentistryOral BiologyOral Health SciencesOral EpidemiologyOral ImmunologyOral MicrobiologyCaries ManagementCaries MicrobiologyCaries PathogenesisCaries PreventionDental CariesMicrobiology Of Dental CariesBiofilm-associated CariesCaries-associated Biofilm EcologyCaries-associated Microbial CommunitiesCaries-associated MicrobiotaDental Biofilm EcologyMicrobiological Etiology Of CariesOral Microbiome Dysbiosis
The recent developments in the science underpinning our knowledge of both the initiation of dental caries and the subsequent behaviour of lesions over time gives us a solid base to understand caries differently. Advances in understanding the human and oral microbiome have come in parallel with the recognition of the importance of balancing protective and pathological risk factors. Caries prevention and management is now about controlling risk factors to maintain a balanced intraoral biofilm ecology that guards against a continuing low pH driven by the frequent consumption of sugars. Thus, caries control is no longer about attempts at eradicating any specific microorganism. Further, the present knowledge leads to the classification of dental caries as a non-communicable disease (NCD), which is vitally important from a policy perspective (both globally and at the country level). Caries shares similar risk factors with other chronic/systemic diseases, which provides opportunities for developing common prevention strategies and promoting health equity through action on the social determinants of health. So, preventing and controlling caries should be integrated across the so-called upstream, midstream and downstream levels and these activities can also help to control other NCDs.
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Revised Estimates for the Number of Human and Bacteria Cells in the Body
Ron Sender, Shai Fuchs, Ron Milo · PLoS Biology · 2016 · 5.1K citations · Full text
The global burden of oral diseases and risks to oral health.
Poul Erik Petersen, Denis Bourgeois, Hiroshi Ogawa et al. · PubMed · 2005 · 2.7K citations · Full text
Global Burden of Oral Conditions in 1990-2010
Wagner Marcenes, N.J. Kassebaum, Eduardo Bernabé et al. · Journal of Dental Research · 2013 · 1.5K citations · Full text
Are dental diseases examples of ecological catastrophes?
Philip Marsh · Microbiology · 2003 · 1.3K citations
The oral microbiome – an update for oral healthcare professionals
Mogens Kilian, Iain Chapple, Matthias Hannig et al. · BDJ · 2016 · 1.2K citations · Full text